CYSTINURIA: AN INBORN CAUSE OF UROLITHIASIS

Cystinuria: an inborn cause of urolithiasis

Abstract Cystinuria (OMIM 220100) is an inborn congenital disorder characterised by a defective cystine metabolism resulting in the formation of cystine stones.Among the heterogeneous group of kidney stone diseases, cystinuria is the only disorder which is exclusively caused by gene mutations.So far, two genes responsible for cystinuria have been i

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Effects of TrkB-related induced metaplasticity within the BLA on anxiety, extinction learning, and plasticity in BLA-modulated brain regions

Abstract Background Neuronal plasticity within the basolateral amygdala (BLA) is fundamental for fear learning.Metaplasticity, the regulation of plasticity states, has emerged as a key mechanism mediating the subsequent impact of emotional and stressful experiences.After mRNA knockdown of synaptic plasticity-related TrkB, we examined the impact of

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